From 2D to 3D microfluidics

Advances in Two-Photon Polymerization allow to create not only 2D and 2.5D microchannel structures but also nearly any 3D object inside an open or even sealed microchannel. Explore Nanoscribe’s 3D Microfabrication solutions for rapid prototyping or fabrication of truly high-precision microfluidic systems.

Microchannel mastering and in-chip printing for microfluidic devices

Various 2.5D and 3D microfluidic elements such as nozzles, filters, mixers and capillary pumps become feasible thanks to the advanced 3D Microfabrication capabilities of Nanoscribe systems. Tailored topographies and smooth surfaces can be produced with high definition. Also sharp micro-needle arrays can be created to control small quantities of liquids, e.g., for precise drug delivery.

Nanoscribe 3D printers offer the highest resolution for additive manufacturing available on the market, achieving minimal feature sizes in the submicron range. The additive approach allows to fabricate microchannel master molds in 2D and 2.5D and to directly print complex microfluidic 3D structures, even in fully sealed microchannels.

For example, mastering and in-chip 3D printing are combined to miniaturize a wet-spinning process in a microfluidic chip: First, a positive master of the microfluidic channel system is printed. Then, by casting PDMS over the printed channels, a negative mold of the channel structures is fabricated. This PDMS slab is sealed by adhering it to a microscope slide using oxygen plasma. The channels are then filled with photoresin, followed by an in-chip 3D printing step. Using Two-Photon Polymerization and an objective lens to focus the laser beam inside the channel, a 3D micronozzle is printed.

Microfluidics
application opportunities

You want to assess the opportunities for your project in microfluidics? Explore the application options of our 3D Microfabrication solutions. Have a look at the 10 most recent scientific publications in microfluidics.
To view the details of the publications and to find more research topics and applications in which Nanoscribe printing systems are successfully used, just enter our premium resources - log in or register for free.

2022/10/21

Reduced rotational flows enable the translation of surface-rolling microrobots in confined spaces

2022/10/10

Influence of the gas viscosity on the stability of flow focusing

2022/06/28

An addressable electrowetting valve for centrifugal microfluidics

2022/04/22

Engineering a living cardiac pump on a chip using high-precision fabrication

2022/04/12

Multiphoton Nanosculpting of Optical Resonant and Nonresonant Microsensors on Fiber Tips

2022/04/10

Wet metallization of 3D printed microarchitectures Application to the manufacturing of bioinspired microswimmers

2022/03/23

Water as a “glue” Elasticity-enhanced wet attachment of biomimetic microcup structures

2022/03/04

Fabrication, Flow Assembly, and Permeation of Microscopic Any-Shape Particles

2022/02/02

Surface Charge Affecting Fluid–Fluid Displacement at Pore Scale

2022/01/06

NMR spectroscopy of a single mammalian early stage embryo

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You get more publication examples and deeper insights within our premium resources. Via a keyword-underpinned database you find more than 1,000 scientific publications of our customers in specific application areas. Make use of the tool to gather valuable know-how and background information about the manifold application options.

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