An overview of BIO INX Photoresins. An overview of BIO INX Photoresins.

BIO INX Photoresins

The biomaterials of our partner BIO INX® include hydrogels and biodegradable photoresins for biological sciences and biotechnology

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Photoresins for Biosciences and Engineering

Nanoscribe’s Two-Photon Polymerization (2PP) technology offers highest resolution for 3D microfabrication on the scale of biological tissues and cells and is therefore a key enabling technology in the field of 3D bioprinting. This requires biomaterials that are compatible with 2PP technology to drive new innovations in life sciences and biology.
Our partner BIO INX develops materials for 3D bioprinting and are world experts in synthesizing biomaterials.

The BIO INX Photoresins we offer include three state-of-the-art bioresins that are specifically optimized for Nanoscribe’s Photonic Professional systems. The direct use of BIO INX bioresins save researchers’ time and costs needed for producing their own bioresins, while also increasing experimental reproducibility across batches. Reducing these common bioprinting hurdles enables Nanoscribe users better to translate their research from the lab to clinical trials.

Dr. Remmi Baker-Sediako, Life Sciences Business Development Manager, Nanoscribe

Dr. Remmi Baker-Sediako, Life Sciences Business Development Manager, Nanoscribe
You had to add inorganic additives to our photoresins to obtain functional or responsive materials. With Hydrobio INX N400 our customers now have a proven product for encapsulating cells as living ingredients for 4D materials.

Bring your applications to life

  • Hydrobio INX N400
  • Hydrotech INX N100
  • Degrad INX N100
  • Specs
Hydrobio INX N400 from BIO INX

Hydrobio INX N400 is the newest BIO INX photoresin, a natural gelatin-based hydrogel designed for live cell encapsulation to enable live cell printing. The material properties of Hydrobio INX N400 have been tailored to promote naturally occurring cellular behaviors ex vivo while maintaining the highest resolution to achieve feature sizes as small as 1 micron. The flexibility of the material provides our researchers with greater freedom of design: cell encapsulation, cell seeding, and a combined approach using both cell encapsulation and seeding. No longer limited to only cell seeding, our researchers can encapsulate cells to either specifically pattern or utilize as building blocks for living material systems, such as tissues.

Advantages
  • Biofunctionalization: Supports cell encapsulation prior to printing for live cell printing
  • Biocompatibility: Supports cell adhesion and proliferation
  • Biodegradability: Enables cells to replace the extracellular matrix with tissue
  • Cell viability: 75% after one week
  • Easy handling: Delivered in a ready-to-use kit containing a concentrated stock solution, dilution buffer and crosslinker for 10 prints in the presence or absence of cells
  • Direct use: Ready for printing in 10 minutes
  • Photodegradability: Enables multiphoton-induced photocleavage after printing
Possible applications
  • Tissue engineering: Fabrication of soft tissues that resemble the natural extracellular matrix.
  • Live cell printing: Human fibroblasts encapsulation
  • Cell seeding: 3D culturing of human-derived cell lines for cellular implants
  • Brain: Culture patient-derived glioma cells for organ-on-a-chips
  • Bone: Co-culturing of preosteoblasts and macrophages on 3D patterned surfaces
  • Breast: Cell invasion studies of human breast cancer cells on 3D scaffolds
Hydrotech INX N100 from Xpect Inx

Hydrotech INX N100 is a synthetic, mechanically robust hydrogel, designed for the 3D Microfabrication of complex architectures for tissue engineering applications. The material is non-biodegradable and biologically inert. However, it can be coated to allow cell adhesion and proliferation.

Advantages
  • Biocompatibility: Biocompatible with no toxic effect on living cells
  • Stability: Forms a biostable hydrogel that sustains 3D cellular structures. Suitable for long term applications
  • Processability: Easy processing into open and complex architectures with minimal deformation
  • Mechanical integrity: Very robust hydrogel suitable for stiff tissue engineering applications
Possible applications
  • Tissue engineering and life science applications that require the soft properties of a hydrogel
  • Skin: Culturing of connective tissue (i.e. fibroblasts)
  • Breasts: Culturing of adipose tissue derived stem cells
  • Liver: HEPG2 viability testing
Degrad INX N100 logo from Xpect Inx

Degrad INX N100 is a biodegradable polyester-based resin designed for the fabrication of complex 3D architectures for tissue engineering applications. The biomaterial is highly flexible and the first commercially available biodegradable photoresin for 2PP applications. Degrad INX N100 is biologically inert. However, it can be coated to allow cell adhesion and proliferation.

Advantages
  • Biocompatibility: Exceptional biocompatibility (ISO 10993-5) with no toxic effect on living cells
  • Biodegradability: Degradable in a long term (3-5 years) when in contact with water or biological fluids
  • Processability: Easy processing into open and complex architectures with minimal deformation
  • High resolution: Highest resolution ever reported for a biodegradable material (< 500 nm)
  • Flexibility: Can generate strong yet flexible structures that are favorable for easy handling and processing
Possible applications
  • Tissue engineering and life science applications requiring biomaterials with high mechanical stability and flexibility
  • Bone and cartilage regeneration
  • Connective tissue: No cytotoxicity for fibroblasts

 

Hydrobio INX N400

Hydrotech INX N100

Degrad INX N100

Material class Natural hydrogel Synthetic hydrogel Polyester
Bio-degradable Yes No Yes
Printable feature size ≥ 1 µm ≤ 1 µm ≤ 1 µm
Mechanical properties Storage modulus
G’ = 2 – 18 kPa
Young’s modulus
E = 30 – 40 MPa
Young’s modulus
E = 50 – 60 MPa
Swelling (vol.) 50 – 250 % n./a. n./a.

Interested in bioprintable materials?

All BIO INX® materials come in ready to use kits and contain everything you need for straightforward print results.

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