Press release
May 15, 2024

Nanoscribe partners with Advanced BioMatrix to offer 4 new bioresins for Quantum X bio

Advanced BioMatrix hydrogels bottles
Advanced BioMatrix hydrogels are suitable for Two-Photon Polymerization (2PP) based high-resolution 3D printing from left to right: PhotoChitosan®, PhotoDextran®, PhotoHA-Stiff® and PhotoGel®. The bioresins must be ordered in a kit with the appropriate photoinitiator for the 2PP-based printing process. For Two-Photon Polymerization, this is LAP.

Nanoscribe announces an exclusive partnership with Advanced BioMatrix to offer four additional hydrogels for Two-Photon Polymerization (2PP) based 3D bioprinting at the scale of biological cells and tissues.

Karlsruhe (DE)/Carlsbad (US). Nanoscribe and Advanced BioMatrix have joined forces to pioneer the field of bioprinting with the launch of four advanced bioresins tailored for Two-Photon Polymerization (2PP) based 3D printing. This partnership combines Nanoscribe's expertise in ultra-precise 3D printing with Advanced BioMatrix's proficiency in biomaterial development, aiming to significantly enhance bioprinting capabilities. These innovative bioresins offer unmatched precision, resolution, and versatility, providing researchers in the life sciences and biomedical fields with new opportunities for discovery and innovation to advance human health.

The new offering of bioresins from Advanced BioMatrix's provides Quantum X bio users with access to an expanded range of materials carefully developed for high-resolution 3D bioprinting. This expansion represents a significant leap forward in the quest for more reproducible, efficient, and customizable bioprinting solutions. To fully leverage the potential of Two-Photon Polymerization and drive innovation in 3D bioprinting, compatible biomaterials are essential. Advanced BioMatrix is a leading developer of materials tailored for 3D biofabrication, enabling groundbreaking discoveries in the life sciences and biology.

High-resolution 3D bioprinting

This collaboration enables the fabrication of intricate structures with unprecedented detail and accuracy. Researchers and scientists can leverage Nanoscribe's Two-Photon Polymerization technology to achieve resolutions on the scale of biological cells and tissues, enabling the creation of sophisticated structures that mimic natural tissue environments. "Advanced BioMatrix resins exceed expectations in quality and versatility. They empower live cell printing with high cell viability and enable the creation of complex 3D hydrogel structures", explains Dr. Marc Hippler, Project Manager for Quantum X bio at Nanoscribe.

Towards tailored solutions
for 3D bioprinting applications

The introduction of these four new bioresins opens up new opportunities in 3D bioprinting. Each resin addresses specific challenges encountered in the field, offering tailored solutions for diverse applications. PhotoGel® (methacrylated gelatin) is the ideal solution for live-cell printing, cell seeding, and various tissue engineering tasks. PhotoHA®-Stiff (methacrylated hyaluronic acid) offers customizable stiffness, ideal for cell seeding, migration studies, and membrane creation. PhotoDextran® (methacrylated dextran) allows for the adjustment of stiffness, making it a versatile option for tissue engineering and constructing extracellular matrix scaffolds with precise mechanical properties. Finally, PhotoChitosan® (methacrylated chitosan) exhibits antimicrobial activity and biodegradability, catering to applications ranging from cell seeding to drug delivery systems and regenerative medicine applications. These bioresins have the potential to revolutionize the life sciences and biology, paving the way for new discoveries and advancements in research and therapeutic development.

 

About Nanoscribe

The medium-sized company develops and produces 3D printers and grayscale lithography systems as well as specially developed printing materials and application-specific solutions for various microfabrication applications. The specialist for additive manufacturing of high-precision structures and objects on the nano-, micro- and mesoscale was founded in 2007 as a spin-off of the Karlsruhe Institute of Technology (KIT) and is part of the BICO Group since June 2021. More than 4,000 users and operators at top universities and innovative companies worldwide benefit from the groundbreaking technology and application tailored solutions for 3D Microfabrication. Nanoscribe has created its strong market leading position through high quality engineering and agility to continuously develop its products to meet customers’ high expectations.

About Advanced BioMatrix

Advanced BioMatrix was founded in 2008 and is a leader in the life science of three dimensional (3D) applications for tissue culture, cell assay, bioprinting and cell proliferation. The products are recognized as the standard for purity, functionality and consistency. Advanced BioMatrix expertise and knowledge are being employed to assure that the products are of the highest quality, consistent from lot-to-lot and easy-to-use for researchers. Advanced BioMatrix materials have been cited in over 5000 publications by researchers worldwide. https://advancedbiomatrix.com/

About BICO

Founded in 2016, BICO (formerly CELLINK) is the leading bio convergence company in the world. By combining different technologies, such as robotics, artificial intelligence, computer science, and 3D bioprinting with biology, we enable our customers to improve people’s health and lives for the better.
The company has a focus on developing technologies that will advance Health 4.0 Next Generation Core Industry Ecosystems that enable tissue engineering, diagnostics, multiomics, and cell line development. BICO’s technologies enable researchers in the life sciences to culture cells in 3D, perform high-throughput drug screening and print human tissues and organs for the medical, pharmaceutical, and cosmetic industries. We create the future of health.
The Group’s instruments in the field amounts to 25,000, including all the top 20 pharmaceutical companies, are being used in more than 65 countries, and have been cited in more than 9,500 publications. BICO is listed on Nasdaq Stockholm under BICO. www.bico.com

 

Captions

Image 1: Advanced BioMatrix hydrogels are suitable for Two-Photon Polymerization (2PP) based high-resolution 3D printing from left to right: PhotoChitosan®, PhotoDextran®, PhotoHA-Stiff® and PhotoGel®. The bioresins must be ordered in a kit with the appropriate photoinitiator for the 2PP-based printing process. For Two-Photon Polymerization, this is LAP.

Image 2: 3D printing hyaluronic acid (HA) from Advanced BioMatrix with Nanoscribe Quantum X bio: The 2.5D topographies printed with HA demonstrate the design freedom and flexibility, ranging from uniform to randomly structured membranes. Top: Printed structures from PhotoHA®-Stiff. Bottom: Designs for the printing job, progressing from an ordered (left) to a disorganized design (right).

Image 3: Animated GIF: Structures made of Advanced BioMatrix bioresin: 3D structure containing living NIH 3T3 fibroblast cells printed from a cell-loaded PhotoGel® (GelMA) bioresin. Cell viability one hour after printing is > 90% as determined by live-dead staining. The animation consists of several focus layers above and mainly within the printed structure.

Right of use and media relations

Our image may be used free of charge for editorial purposes. Please state the source as follows: "Image: Nanoscribe, www.nanoscribe.com". The image must not be used for commercial purposes or passed on to third parties.
In case of questions or if you would like to be added to our press mailing list, please do not hesitate to contact Dr. Saskia Braun, media@nanoscribe.com.

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